Consensus Recommendations on Estrogen Receptor Testing in Breast Cancer By Immunohistochemistry

被引：89

作者：

Yaziji, Hadi ^{[1
]}

Taylor, Clive R. ^{[2
]}

Goldstein, Neal S. ^{[4
]}

Dabbs, David J. ^{[5
]}

Hammond, Elizabeth H. ^{[6
]}

Hewlett, Bryan ^{[15
]}

Floyd, Alton D. ^{[1
]}

Barry, Todd S. ^{[3
]}

Martin, Alvn W. ^{[7
]}

Badve, Sunil ^{[8
]}

Baehner, Frederick ^{[8
]}

Cartun, Richard W. ^{[9
,10
]}

Eisen, Richard N.

Swanson, Paul E. ^{[11
]}

Hewitt, Stephen M. ^{[12
]}

Vyberg, Mogen ^{[14
]}

Hicks, David G. ^{[13
]}

机构：

[1] Vitro Mol Labs, Miami, FL 33143 USA

[2] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA

[3] Clarient, Aliso Viejo, CA USA

[4] Adv Diag Lab, Redford, MI USA

[5] Magee Womens Hosp, Pittsburgh, PA USA

[6] LDS Hosp, Salt Lake City, UT USA

[7] Univ Louisville, Sch Med, Louisville, KY 40292 USA

[8] Indiana Univ, Sch Med, Indianapolis, IN USA

[9] Hartford Hosp, Hartford, CT 06115 USA

[10] Greenwich Hosp, Greenwich, CT USA

[11] Univ Washington, Sch Med, Seattle, WA USA

[12] NIH, Bethesda, MD 20892 USA

[13] Univ Rochester, Sch Med, Rochester, NY USA

[14] NordiQC, Aalborg, Denmark

[15] Lab Serv, Qual Management Program, Toronto, ON, Canada

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2008年 / 16卷 / 06期

关键词：

immunohistochemistry; standardization; estrogen receptor; ER; IHC; breast cancer;

D O I：

10.1097/PAI.0b013e31818a9d3a

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Estrogen receptor (ER) status in breast cancer is currently the most important predictive biomarker that determines breast cancer prognosis after treatment with endocrine therapy. Although immunohistochemistry has been widely viewed Lis the gold standard methodology for ER testing in breast cancer, lack of standardized procedures, and lack of regulatory adherence to testing guidelines has resulted in high rates of "False-negative" results worldwide. Standardized testing is only possible after all aspects of ER testing-preanalytical, analytical, and postanalytical, have been closely controlled. A meeting of the "ad-hoc committee" of expert pathologists., technologists, and scientists. representing academic centers, reference laboratories, and various agencies, issued standardization testing recommendations, aimed at optimization of clinical ER testing environment, as a step toward improved standardized testing.

引用

页码：513 / 520

页数：8

共 29 条

[1]

Allred DC, 2005, AM J CLIN PATHOL, V124, P474

[2] The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer [J].