First synthesis of both enantiomers of the biotin vitamer 8-amino-7-oxopelargonic acid

被引：29

作者：

Lucet, D ^{[1
]}

LeGall, T ^{[1
]}

Mioskowski, C ^{[1
]}

Ploux, O ^{[1
]}

Marquet, A ^{[1
]}

机构：

[1] UNIV PARIS 06,LAB CHIM ORGAN BIOL,URA CNRS 493,F-75252 PARIS,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 04期

关键词：

D O I：

10.1016/0957-4166(96)00098-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A short and efficient synthesis of both 8-amino-7-oxopelargonic acid enantiomers from D or L-alanine is presented, The key step of this first chemical synthesis is the nonracemizing Horner-Wadsworth-Emmons reaction of a beta-ketophosphonate 3 and benzyl 4-formylbutanoate. The growth-promoting effect of the enantiomers was tested on Saccharomyces cerevisiae. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：985 / 988

页数：4

共 17 条

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