End-resection at DNA double-strand breaks in the three domains of life

被引：33

作者：

Blackwood, John K. ^{[1
]}

Rzechorzek, Neil J. ^{[1
]}

Bray, Sian M. ^{[1
]}

Maman, Joseph D. ^{[1
]}

Pellegrini, Luca ^{[1
]}

Robinson, Nicholas P. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2013年 / 41卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

COGNATE CHI SEQUENCE; ESCHERICHIA-COLI; RECBCD ENZYME; MRE11; COMPLEX; HOMOLOGOUS RECOMBINATION; RECF PATHWAY; ADDAB HELICASE/NUCLEASE; CRYSTAL-STRUCTURE; GENETIC-ANALYSIS; MOTOR-NUCLEASE;

D O I：

10.1042/BST20120307

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

During DNA repair by HR (homologous recombination), the ends of a DNA DSB (double-strand break) must be resected to generate single-stranded tails, which are required for strand invasion and exchange with homologous chromosomes. This 5'-3' end-resection of the DNA duplex is an essential process, conserved across all three domains of life: the bacteria, eukaryota and archaea. In the present review, we examine the numerous and redundant helicase and nuclease systems that function as the enzymatic analogues for this crucial process in the three major phylogenetic divisions.

引用

页码：314 / 320

页数：7

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