共 28 条
Regulation by Nucleoid-Associated Proteins at the Escherichia coli nir Operon Promoter
被引:26
作者:

Browning, Douglas F.
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Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

Cole, Jeffrey A.
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Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

Busby, Stephen J. W.
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Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
机构:
[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
基金:
英国惠康基金;
关键词:
D O I:
10.1128/JB.01015-08
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The Escherichia coli K-12 nir operon promoter can be fully activated by binding of the regulator of fumarate and nitrate reduction (FNR) to a site centered at position -41.5 upstream of the transcript start, and this activation is modulated by upstream binding of the integration host factor (IHF) and Fis ( factor for inversion stimulation) proteins. Thus, transcription initiation is repressed by the binding of IHF and Fis to sites centered at position -88 (IHF I) and position -142 (Fis I) and activated by IHF binding to a site at position -115 (IHF II). Here, we have exploited mutational analysis and biochemistry to investigate the actions of IHF and Fis at these sites. We show that the effects of IHF and Fis are position dependent and that IHF II functions independently of IHF I and Fis I. Using in vitro assays, we report that IHF and Fis repress transcription initiation by interfering with RNA polymerase binding. Differences in the upstream IHF and Fis binding sites at the nir promoter in related enteric bacteria fix the level of nir operon expression under anaerobic growth conditions.
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页码:7258 / 7267
页数:10
相关论文
共 28 条
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Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
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Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

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