Diastereoselective Palladium-Catalyzed α-Arylation of 4-Substituted Cyclohexyl Esters

被引：30

作者：

Bercot, Eric A. ^{[1
]}

Caille, Seb ^{[1
]}

Bostick, Tracy M. ^{[1
]}

Ranganathan, Krishnakumar ^{[1
]}

Jensen, Randy ^{[1
]}

Faul, Margaret M. ^{[1
]}

机构：

[1] Amgen Inc, Chem Proc R&D, Thousand Oaks, CA 91320 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 22期

关键词：

D O I：

10.1021/ol8021758

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diastereoselective palladium-catalyzed arylation of 4-substituted cyclohexyl esters has been developed. The reaction proceeds at room temperature in the presence of [(t-Bu(3)P)PdBr](2) providing products in up to 37:1 dr.

引用

页码：5251 / 5254

页数：4

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