Induction of Escherichia coli chromosomal mazEF by stressful conditions causes an irreversible loss of viability

被引：77

作者：

Kolodkin-Gal, I ^{[1
]}

Engelberg-Kulka, H ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Mol Biol, IL-91120 Jerusalem, Israel

来源：

JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 09期

关键词：

D O I：

10.1128/JB.188.9.3420-3423.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

mazEF is a stress-induced toxin-antitoxin module located on the chromosomes of many bacteria. Here we induced Escherichia coli chromosomal mazEF by various stressful conditions. We found an irreversible loss of viability, which is the basic characteristic of cell death. These results further support our previous conclusion that E. coli mazEF mediation of cell death is not a passive process, but an active and genetically "programmed" death response.

引用

页码：3420 / 3423

页数：4

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