The role of plasma-binding proteins in the cellular uptake of lipophilic vitamins and steriods

被引：27

作者：

Andreassen, T. K. ^{[1
]}

机构：

[1] Aarhus Univ, Dept Biochem Med, DK-8000 Aarhus C, Denmark

来源：

HORMONE AND METABOLIC RESEARCH | 2006年 / 38卷 / 04期

关键词：

SHBG; DBP; steroids; lipophilic molecules; binding proteins; receptor-mediated endocytosis; uptake; transport;

D O I：

10.1055/s-2006-925348

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Steroid hormones and many other lipophilic compounds are believed to enter cells solely by free diffusion through the plasma membrane. However, recent work using a megalin-deficient mouse model has identified a new endocytic pathway responsible for the delivery of steroids to renal and gonadal tissues. This review describes these new pathways for uptake of 25-hydroxy-vitamin-D3 and the gonadal sex-steroids (17 beta-estradiol and testosterone) bound to vitamin D-binding protein and sex hormone-binding globulin respectively. Furthermore examples of other lipophilic molecules that enter cells by receptor-mediated pathways will be presented and the receptors responsible for their uptake described.

引用

页码：279 / 290

页数：12

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