Construction of double-helical DNA structures based on dinucleotide building blocks

被引：14

作者：

Hunter, CA

Lu, XJ

机构：

[1] Krebs Institute for Biomolecular Science, Department of Chemistry, University of Sheffield, Sheffield

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 1997年 / 14卷 / 06期

关键词：

D O I：

10.1080/07391102.1997.10508177

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a new method for building full 3-D structures of DNA sequences. A database of the conformational properties of dinucleotide steps has been compiled using X-ray crystal structures of oligonucleotides. The protocol uses these dinucleotides as building blocks to generate three dimensional structures of any required sequence in any required conformation.

引用

收藏

页码：747 / 756

页数：10

相关论文

共 27 条

[1]

BANSAL M, 1995, COMPUT APPL BIOSCI, V11, P281

[2] THE NUCLEIC-ACID DATABASE - A COMPREHENSIVE RELATIONAL DATABASE OF 3-DIMENSIONAL STRUCTURES OF NUCLEIC-ACIDS [J].

BERMAN, HM ;

OLSON, WK ;

BEVERIDGE, DL ;

WESTBROOK, J ;

GELBIN, A ;

DEMENY, T ;

HSIEH, SH ;

SRINIVASAN, AR ;

SCHNEIDER, B .

BIOPHYSICAL JOURNAL, 1992, 63 (03) :751-759

[3] The crystal structure analysis of d(CGCGAASSCGCG)(2), a synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides [J].

Boggon, TJ ;

Hancox, EL ;

McAuleyHecht, KE ;

Connolly, BA ;

Hunter, WN ;

Brown, T ;

Walker, RT ;

Leonard, GA .

NUCLEIC ACIDS RESEARCH, 1996, 24 (05) :951-961

[4]

CALLADINE CR, 1992, MOL IT WORKS

[5]

Carter ES, 1996, COMPUT APPL BIOSCI, V12, P25

[6] DEFINITIONS AND NOMENCLATURE OF NUCLEIC-ACID STRUCTURE PARAMETERS [J].

DIEKMANN, S .

JOURNAL OF MOLECULAR BIOLOGY, 1989, 205 (04) :787-791

[7] CRYSTAL-LATTICE PACKING IS IMPORTANT IN DETERMINING THE BEND OF A DNA DODECAMER CONTAINING AN ADENINE TRACT [J].

DIGABRIELE, AD ;

SANDERSON, MR ;

STEITZ, TA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (06) :1816-1820

[8] Propeller-twisting of base-pairs and the conformational mobility of dinucleotide steps in DNA [J].

ElHassan, MA ;

Calladine, CR .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 259 (01) :95-103

[9] THE ASSESSMENT OF THE GEOMETRY OF DINUCLEOTIDE STEPS IN DOUBLE-HELICAL DNA - A NEW LOCAL CALCULATION SCHEME [J].

ELHASSAN, MA ;

CALLADINE, CR .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 251 (05) :648-664

[10]

ELHASSAN MA, 1995, THESIS U CAMBRIDGE E