Glutamate is the fast excitatory transmitter in mammalian brains. It binds to two major classes of glutamate receptors: ionotropic and metabotropic receptors. lonotropic receptors contain three subtype receptors, including N-methyl-D-aspartate (NMDA) receptors. Activation of NMDA receptors is important for initiating long-lasting changes in synapses. In the forebrain structures that are known to contribute to the formation and storage of information, NMDA receptors have an important role in persistent inflammatory pain by reinforcing glutamate sensory transmission. Mice with enhanced forebrain NMDA receptor function demonstrate selective enhancement of persistent pain and allodynia. Drugs targeting NMDA NR2B subunits in the forebrain could serve as a new class of medicine for controlling persistent pain in humans.
机构:
UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL & NEUROL, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT PHYSIOL & NEUROL, SAN FRANCISCO, CA 94143 USA
BASBAUM, AI
;
FIELDS, HL
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机构:
UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL & NEUROL, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT PHYSIOL & NEUROL, SAN FRANCISCO, CA 94143 USA
机构:
UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL & NEUROL, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT PHYSIOL & NEUROL, SAN FRANCISCO, CA 94143 USA
BASBAUM, AI
;
FIELDS, HL
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL & NEUROL, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT PHYSIOL & NEUROL, SAN FRANCISCO, CA 94143 USA