Identification of genes encoding two-component lantibiotic production in Staphylococcus aureus C55 and other phage group II S-aureus strains and demonstration of an association with the exfoliative toxin B gene

被引:50
作者
Navaratna, MADB
Sahl, HG
Tagg, JR [1 ]
机构
[1] Univ Otago, Dept Microbiol, Dunedin, New Zealand
[2] Univ Bonn, Inst Med Mikrobiol & Immunol, D-53105 Bonn, Germany
关键词
D O I
10.1128/IAI.67.8.4268-4271.1999
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The production of exfoliative toxin B (ET-B), but not ET-A, was shown to be specifically associated with production of a highly conserved two-component lantibiotic peptide system in phage group II Staphylococcus aureus. Two previously studied but incompletely characterized S. aureus bacteriocins, staphylococcins C55 and BacR1, were found to be members of this lantibiotic system, and considerable homology was also found with the two-component Lactococcus lactis baeteriocin, lacticin 3147. sac alpha A and sac beta A, the structural genes of the lantibiotics staphylococcins C55 alpha and C55 beta and two putative lantibiotic processing genes, sacM1 and sacT, were localized together with the ET-B structural gene to a single 32-kb plasmid in strain C55. In-eversible loss of both ET-B and two-component lantibiotic production occurs during laboratory passage of ET-B-positive S. aureus strains, particularly at elevated temperatures.
引用
收藏
页码:4268 / 4271
页数:4
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