Early growth response-1 in cardiovascular pathobiology

被引：254

作者：

Khachigian, LM ^{[1
]}

机构：

[1] Univ New S Wales, Dept Pathol, Ctr Vasc Res, Sydney, NSW 2052, Australia

[2] Prince Wales Hosp, Dept Haematol, Sydney, NSW, Australia

来源：

CIRCULATION RESEARCH | 2006年 / 98卷 / 02期

关键词：

Egr-1; atherosclerosis; vascular injury; angiogenesis; ischemia and ischemia-reperfusion; allograft rejection; cardiac hypertrophy;

D O I：

10.1161/01.RES.0000200177.53882.c3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The immediate-early gene product and zinc finger transcription factor early growth response (Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes. This article reviews the amassing recent evidence implicating Egr-1 in atherosclerosis, intimal thickening after acute vascular injury, ischemic pathology, angiogenesis, allograft rejection, and cardiac hypertrophy.

引用

页码：186 / 191

页数：6

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