Immunity and correlates of protection for rotavirus vaccines

被引：186

作者：

Franco, MA

Angel, J

Greenberg, HB

机构：

[1] Pontificia Univ Javeriana, Inst Genet Humana, Bogota 4062, Colombia

[2] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Microbiol, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Dept Immunol, Stanford, CA 94305 USA

来源：

VACCINE | 2006年 / 24卷 / 15期

关键词：

rotavirus; immunity; vaccine;

D O I：

10.1016/j.vaccine.2005.12.048

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rotaviruses are the most common cause of severe, dehydrating diarrhea in children worldwide. The tremendous global incidence of rotavirus gastroenteritis, especially in developing Countries, emphasizes the need for vaccines to prevent associated morbidity and mortality. However, immunity to rotavirus is not completely understood. At this time, total serum RV IgA, measured shortly after infection, appears to be the best marker of protection against rotavirus. This review describes the current understanding of rotavirus immunity, including mechanisms of protection against rotavirus from selected animal models, and correlates of protection associated with natural infection or vaccination from humans. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2718 / 2731

页数：14

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