Comparative genomics and genome evolution in yeasts

被引:50
作者
Wolfe, KH [1 ]
机构
[1] Univ Dublin Trinity Coll, Dept Genet, Smurfit Inst, Dublin 2, Ireland
关键词
Saccharomyces cerevisiae; evolution; bioinformatics; genomics;
D O I
10.1098/rstb.2005.1799
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Yeasts provide a powerful model system for comparative genomics research. The availability of multiple complete genome sequences from different fungal groups-currently 18 hemiascomycetes, 8 euascomycetes and 4 basidiomycetes-enables us to gain a broad perspective on genome evolution. The sequenced genomes span a continuum of divergence levels ranging from multiple individuals within a species to species pairs with low levels of protein sequence identity and no conservation of gene order. One of the most interesting emerging areas is the growing number of events such as gene losses, gene displacements and gene relocations that can be attributed to the action of natural selection.
引用
收藏
页码:403 / 412
页数:10
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