Using a longitudinal sample of medical technologists (MTs) this study found, after controlling for prior overall job satisfaction, individual difference, and organization-level variables, that task responsibilities and employee performance appraisal satisfaction significantly affected subsequent overall MT job satisfaction. Overall job satisfaction significantly declined for repeat-respondents over the ii-year period. Data also suggested that the impact of task responsibilities on overall job satisfaction can dissipate over time, and that the supervisor's role in affecting employee job satisfaction is important. Results and limitations are discussed.