Blackberry extracts inhibit UV-induced mutagenesis in Salmonella typhimurium TA100

被引：19

作者：

Tate, P

Stanner, A

Shields, K

Smith, S

Larcom, L ^{[1
]}

机构：

[1] Clemson Univ, Dept Biol Sci, Clemson, SC 29634 USA

[2] Clemson Univ, Dept Phys & Astron, Clemson, SC 29634 USA

[3] Greenville Mem Hosp Syst, Greenville, SC 29605 USA

来源：

NUTRITION RESEARCH | 2006年 / 26卷 / 02期

关键词：

blackberry; fruit extracts; mutagenesis; UV radiation; anticancer compounds; ames assay; Salmonella typhimurium;

D O I：

10.1016/j.nutres.2005.11.005

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The development of metastatic cancer involves a series of mutagenic events. Compounds in blackberries effectively block mutagenesis by metabolically activated carcinogens and can serve as effective anticancer agents. We have compared the effects of 8 different varieties of blackberry on UV-C-induced mutagenesis in Salmonella typhimurium TA100. The 8 varieties were cultivated under identical conditions and harvested as ripe berries. Two varieties had no effect on UV-C-induced mutagenesis. Two showed significant suppression of mutagenesis. The other 4 had intermediate effects. Berry extracts were added only after irradiation of the cells was complete. The results imply that some varieties of blackberries contain substances that might inhibit error-prone DNA repair. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：100 / 104

页数：5

共 32 条

[1] PROTECTION AGAINST ULTRAVIOLET-B RADIATION-INDUCED EFFECTS IN THE SKIN OF SKH-1 HAIRLESS MICE BY A POLYPHENOLIC FRACTION ISOLATED FROM GREEN TEA [J].