Immune suppression as the etiology of failure to detect anti-HBc antibodies in patients with chronic hepatitis B virus infection

被引：33

作者：

Avettand-Fenoel, V.

Thabut, D.

Katlama, C.

Poynard, T.

Thibault, V.

机构：

[1] Grp Hosp Pitie Salpetriere, Dept Virol, F-75634 Paris, France

[2] Grp Hosp Pitie Salpetriere, Dept Infect Dis, F-75634 Paris, France

[3] Grp Hosp Pitie Salpetriere, Hepatogastroenterol Dept, F-75634 Paris, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2006年 / 44卷 / 06期

关键词：

D O I：

10.1128/JCM.00234-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A lack of anti-HBc antibodies during chronic hepatitis B virus infection is a serological pattern that is rarely observed. In our series of 39 patients with such a confirmed profile, mutations within the precore/core gene were rarely found and the lack of antibody detection was mostly explained by concurrent immunosuppression and the low sensitivities of the serological assays.

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页码：2250 / 2253

页数：4

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