Microwave-assisted synthesis of novel 5-trichloromethyl-4,5-dihydro-1H-1-pyrazole methyl esters under solvent free conditions

被引：27

作者：

Martins, MAP ^{[1
]}

Beck, P ^{[1
]}

Machado, P ^{[1
]}

Brondani, S ^{[1
]}

Moura, S ^{[1
]}

Zanatta, N ^{[1
]}

Bonacorso, HG ^{[1
]}

Flores, AFC ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, NUQUIMHE, BR-97105900 Santa Maria, RS, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2006年 / 17卷 / 02期

关键词：

pyrazoles; enones; microwave irradiations; green chemistry;

D O I：

10.1590/S0103-50532006000200027

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Twelve novel 5-trichloromethyl-4,5-dihydro-1H-1-pyrazole ethyl esters have been synthesized in good yields ( 70-98%) by using environmentally benign microwave induced techniques. The compounds were synthesized from the cyclocondensation of 1,1,1-trichloro-4alkoxy-3-alken-2-ones [CCl3C(O)C(R-2)= C(R-1) OR, where R, R-2 = H, alkyl; R-1 = H, alkyl and aryl] with hydrazine methyl carboxylate. The advantages obtained by the using of microwave irradiation under solvent-free conditions, rather than a conventional method, were demonstrated.

引用

页码：408 / 411

页数：4

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