Elevated soluble CD 14 receptors and altered cytokines in chronic heart failure

被引：329

作者：

Anker, SD

Egerer, KR

Volk, HD

Kox, WJ

PooleWilson, PA

Coats, AJS

机构：

[1] HUMBOLDT UNIV BERLIN,HOSP CHARITE,DEPT ANAESTHESIOL & INTENS CARE MED,BERLIN,GERMANY

[2] HUMBOLDT UNIV BERLIN,HOSP CHARITE,DEPT IMMUNOL,BERLIN,GERMANY

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1997年 / 79卷 / 10期

关键词：

D O I：

10.1016/S0002-9149(97)00159-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We hypothesized that in patients with chronic heart failure mesenteric venous congestion leads to increased bowel permeability, bacterial translocation, and thereby endotoxin release; the increased endo-toxin challenge then causes immune activation with increased soluble CD14 levels and tumor necrosis factor (TNF)-alpha production. Patients with high soluble CD14 levels (indicative of endotoxin-cell interaction) have markedly increased plasma levels of TNF-alpha, soluble TNF receptors 1 and 2, and intracellular adhesion molecule-1, supporting this hypothesis.

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页码：1426 / &

页数：7

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