New agents for chemoprevention of prostate cancer

被引:14
作者
Sporn, MB [1 ]
机构
[1] Dartmouth Med Sch, Dept Pharmacol, Hanover, NH 03755 USA
关键词
D O I
10.1159/000019873
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The magnitude of the problem of prostate cancer, and the failure of conventional chemotherapy and surgery to effect a marked diminution in the total number of deaths from this disease, now indicate that chemoprevention of prostatic carcinogenesis must be seriously considered. We describe the development of a new system for quantitating the process of prostatic carcinogenesis in an experimental animal, and the use of this system to demonstrate that the retinoid, 4-hydroxyphenylretinamide, the deltanoid, Ro24-5531, and the estrogen analog, tamoxifen, all are effective agents for prevention of experimental prostate cancer.
引用
收藏
页码:420 / 423
页数:4
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