Systems biology: personalized medicine for the future?

被引：55

作者：

Chen, Rui ^{[1
]}

Snyder, Michael ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2012年 / 12卷 / 05期

基金：

美国国家卫生研究院;

关键词：

GENOME; MUTATIONS; MICRORNA; PATIENT; LINKS;

D O I：

10.1016/j.coph.2012.07.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Systems biology is actively transforming the field of modern health care from symptom-based disease diagnosis and treatment to precision medicine in which patients are treated based on their individual characteristics. Development of high-throughput technologies such as high-throughout sequencing and mass spectrometry has enabled scientists and clinicians to examine genomes, transcriptomes, proteomes, metabolomes, and other omics information in unprecedented detail. The combined 'omics' information leads to a global profiling of health and disease, and provides new approaches for personalized health monitoring and preventative medicine. In this article, we review the efforts of systems biology in personalized medicine in the past 2 years, and discuss in detail achievements and concerns, as well as highlights and hurdles for future personalized health care.

引用

页码：623 / 628

页数：6

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