Reovirus: Viral therapy for cancer 'as nature intended'

被引：43

作者：

Comins, C. ^{[1
]}

Heinemann, L. ^{[1
]}

Harrington, K. ^{[2
]}

Melcher, A. ^{[3
]}

De Bono, J. ^{[2
]}

Pandha, H. ^{[1
]}

机构：

[1] Univ Surrey, Postgrad Med Sch, Dept Oncol, Guildford GU2 7WG, Surrey, England

[2] Inst Canc Res, London SW3 6JB, England

[3] St James Hosp, Leeds LS9 7TF, W Yorkshire, England

来源：

CLINICAL ONCOLOGY | 2008年 / 20卷 / 07期

关键词：

chemotherapy; oncolytic virus; radiotherapy; reovirus;

D O I：

10.1016/j.clon.2008.04.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Oncolytic viruses are tumour selective and able to lyse cancer cells after infection. Reovirus is an example of a wild-type oncolytic virus and is currently being investigated as a potential novel therapy for cancer. This overview gives a brief description of what is known about reovirus biology and summarises the preclinical data related to its oncolytic ability. The completed and ongoing clinical trials involving reovirus, both as a single agent and in combination with chemotherapy and radiotherapy, will be reviewed and their results discussed. Many of these clinical studies are being conducted by centres in the UK.

引用

页码：548 / 554

页数：7

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