Identification of a genetic cluster influencing memory performance and hippocampal activity in humans

被引：128

作者：

de Quervain, DJF ^{[1
]}

Papassotiropoulos, A

机构：

[1] Univ Zurich, Div Psychiat Res, CH-8057 Zurich, Switzerland

[2] Univ Zurich, Ctr Integrat Human Physiol, CH-8057 Zurich, Switzerland

[3] Translat Genom Res Inst, Neurogenom Div, Phoenix, AZ 85004 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 11期

关键词：

genes; molecular cascade; learning;

D O I：

10.1073/pnas.0510212103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Experimental work in animals has shown that memory formation depends on a cascade of molecular events. Here we show that variability of human memory performance is related to variability in genes encoding proteins of this signaling cascade, including the NMDA and metabotrobic glutamate receptors, adenylyl cyclase, CAMKII, PKA, and PKC. The individual profile of genetic variability in these signaling molecules correlated significantly with episodic memory performance (P < 0.00001). Moreover, functional MRI during memory formation revealed that this genetic profile correlated with activations in memory-related brain regions, including the hippocampus and parahippocampal gyrus. The present study indicates that genetic variability in the human homologues of memory-related signaling molecules contributes to interindividual differences in human memory performance and memory-related brain activations.

引用

页码：4270 / 4274

页数：5

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