Plasma orexin-A is lower in patients with narcolepsy

被引：61

作者：

Higuchi, S

Usui, A

Murasaki, M

Matsushita, S

Nishioka, N

Yoshino, A

Matsui, T

Muraoka, H

Ishizuka, Y

Kanba, S

Sakurai, T

机构：

[1] Kurihama Natl Hosp, Natl Alcoholism Ctr, Inst Clin Res, Yokosuka, Kanagawa 2390841, Japan

[2] Yamanashi Med Univ, Dept Neuropsychiat, Tamaho, Yamanashi 4093898, Japan

[3] Yutaka Clin, Sagamihara, Kanagawa 2280803, Japan

[4] Natl Def Med Coll, Dept Psychiat, Tokorozawa, Saitama 3598513, Japan

[5] Tohoku Univ, Sch Med, Dept Geriatr Med, Aoba Ku, Sendai, Miyagi 9808574, Japan

[6] Tokyo Metropolitan Tama Geriatr Hosp, Dept Psychiat, Tokyo 189002, Japan

[7] Univ Tsukuba, Inst Basic Med Sci, Dept Pharmacol, Tsukuba, Ibaraki 3058575, Japan

来源：

NEUROSCIENCE LETTERS | 2002年 / 318卷 / 02期

关键词：

orexin; hypocretin; plasma; concentration; narcolepsy;

D O I：

10.1016/S0304-3940(01)02476-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recently identified hypothalamic peptides called orexins (or hypocretins) have been implicated in the sleep-wake cycle and in sleep disorder narcolepsy. Neuropathological studies have shown that in patients with narcolepsy, global reduction in the expression of orexins occurs due to the loss of orexin neurons in the hypothalamus. Cerebrospinal fluid analysis has confirmed a reduced or undetectable level of orexin-A in most narcolepsy patients. In this study, measurement of plasma orexin showed significantly lower concentrations in patients with narcolepsy than in age- and gender-matched normal controls. These data suggest that low levels of orexin-A in plasma could serve as a biological marker for narcolepsy. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：61 / 64

页数：4

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