Kaposi's sarcoma (KS)-associated herpesvirus-like DNA sequences in peripheral blood mononuclear cells: Association with KS and persistence in patients receiving anti-herpesvirus drugs

被引：57

作者：

Humphrey, RW

OBrien, TR

Newcomb, FM

Nishihara, H

Wyvill, KM

Ramos, GA

Saville, MW

Goedert, JJ

Straus, SE

Yarchoan, R

机构：

[1] NCI,VIRAL EPIDEMIOL BRANCH,NIH,BETHESDA,MD 20892

[2] NIAID,CLIN INVEST LAB,BETHESDA,MD 20892

来源：

BLOOD | 1996年 / 88卷 / 01期

关键词：

D O I：

10.1182/blood.V88.1.297.bloodjournal881297

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Herpesvirus-like DNA sequences (KSHV/HHV-8) have recently been described in AIDS-associated Kaposi's sarcoma (KS) lesions. Many questions remain regarding the role of this virus in KS and the therapeutic implications of this finding. In the current study, KSHV/HHV-8 DNA was detected in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus (HIV)-infected patients with KS (34/98) more often than in HIV-infected individuals without KS (12/64, P = .03). The detection of KSHV/HHV-8 DNA did not correlate with the CD4 lymphocyte count. Five patients demonstrated KSHV/HHV-8 DNA in their PBMCs during administration of intravenous foscarnet and/or ganciclovir. The continued detection of KSHV/HHV-8 DMA in the PBMCs of patients receiving these anti-herpesvirus drugs has potential implications regarding the virus-cell relationship of KSHV/HHV-8, as well as for the value of these drugs in treating or preventing KS, but additional studies are needed.

引用

页码：297 / 301

页数：5

共 18 条

[1] CHARACTERIZATION OF A DISTINCT SUBGROUP OF HIGH-RISK PERSONS WITH KAPOSIS-SARCOMA AND GOOD PROGNOSIS WHO PRESENT WITH NORMAL T4 CELL NUMBER AND T4-T8 RATIO AND NEGATIVE HTLV-III/LAV SEROLOGIC TEST-RESULTS [J].