Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers

被引：329

作者：

Matsumoto, M

Mariathasan, S

Nahm, MH

Baranyay, F

Peschon, JJ

Chaplin, DD

机构：

[1] WASHINGTON UNIV,SCH MED,CTR IMMUNOL,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,HOWARD HUGHES MED INST,ST LOUIS,MO 63110

[3] IMMUNEX RES & DEV CORP,SEATTLE,WA 98101

来源：

SCIENCE | 1996年 / 271卷 / 5253期

关键词：

D O I：

10.1126/science.271.5253.1289

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In mice deficient in either lymphotoxin-alpha (LT-alpha) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow.

引用

页码：1289 / 1291

页数：3

共 33 条

[1] BANKS TA, 1995, J IMMUNOL, V155, P1685
[2] CRYSTAL-STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX - IMPLICATIONS FOR TNF RECEPTOR ACTIVATION
BANNER, DW
DARCY, A
JANES, W
GENTZ, R
SCHOENFELD, HJ
BROGER, C
LOETSCHER, H
LESSLAUER, W
[J]. CELL, 1993, 73 (03) : 431 - 445
[3] Beutler B, 1992, TUMOR NECROSIS FACTO
[4] BROWNING J, 1989, J IMMUNOL, V143, P1859
[5] BROWNING JL, 1991, J IMMUNOL, V147, P1230
[6] LYMPHOTOXIN-BETA, A NOVEL MEMBER OF THE TNF FAMILY THAT FORMS A HETEROMERIC COMPLEX WITH LYMPHOTOXIN ON THE CELL-SURFACE
BROWNING, JL
NGAMEK, A
LAWTON, P
DEMARINIS, J
TIZARD, R
CHOW, EPC
HESSION, C
OBRINEGRECO, B
FOLEY, SF
WARE, CF
[J]. CELL, 1993, 72 (06) : 847 - 856
[7] BROWNING JL, 1995, J IMMUNOL, V154, P33
[8] A Lymphotoxin-β-Specific Receptor
Crowe, Paul D.
VanArsdale, Todd L.
Walter, Barbara N.
Ware, Carl F.
Hession, Catherine
Ehrenfels, Barbara
Browning, Jeffrey L.
Din, Wenie S.
Goodwin, Raymond G.
Smith, Craig A.
[J]. JOURNAL OF IMMUNOLOGY, 2014, 192 (05) : 2015 - 2018
[9] Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin
De Togni, Pietro
Goellner, Josphe
Ruddle, Nancy H.
Streeter, Philip R.
Fick, Andrea
Mariathasan, Sanjeev
Smith, Stacy C.
Carison, Rebecca
Shonnick, Laurie P.
strauss-Schoenberger, Jena
Russell, John H.
Karr, Robert
Chaplin, David D.
[J]. JOURNAL OF IMMUNOLOGY, 2014, 192 (05) : 2010 - 2014
[10] ECK MJ, 1992, J BIOL CHEM, V267, P2119

← 1 2 3 4 →