An investigation of polymorphism in the interleukin-10 gene promoter

被引：1480

作者：

Turner, DM ^{[1
]}

Williams, DM ^{[1
]}

Sankaran, D ^{[1
]}

Lazarus, M ^{[1
]}

Sinnott, PJ ^{[1
]}

Hutchinson, IV ^{[1
]}

机构：

[1] UNIV MANCHESTER,SCH BIOL SCI,MANCHESTER,LANCS,ENGLAND

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 1997年 / 24卷 / 01期

关键词：

D O I：

10.1111/j.1365-2370.1997.tb00001.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.

引用

收藏

页码：1 / 8

页数：8

相关论文

共 31 条

[1]

BLAY JY, 1993, BLOOD, V82, P2169

[2] INTERLEUKIN-10 INHIBITS T-CELL ALLOREACTION INDUCED BY HUMAN DENDRITIC CELLS [J].

CAUX, C ;

MASSACRIER, C ;

VANBERVLIET, B ;

BARTHELEMY, C ;

LIU, YJ ;

BANCHEREAU, J .

INTERNATIONAL IMMUNOLOGY, 1994, 6 (08) :1177-1185

[3] HIGH-LEVEL OF INTERLEUKIN-10 PRODUCTION BY THE ACTIVATED T-CELL POPULATION WITHIN THE RHEUMATOID SYNOVIAL-MEMBRANE [J].

COHEN, SBA ;

KATSIKIS, PD ;

CHU, CQ ;

THOMSSEN, H ;

WEBB, LMC ;

MAINI, RN ;

LONDEI, M ;

FELDMANN, M .

ARTHRITIS AND RHEUMATISM, 1995, 38 (07) :946-952

[4] ELEVATED INTERLEUKIN-10 LEVELS IN PATIENTS WITH RHEUMATOID-ARTHRITIS [J].

CUSH, JJ ;

SPLAWSKI, JB ;

THOMAS, R ;

MCFARLIN, JE ;

SCHULZEKOOPS, H ;

DAVIS, LS ;

FUJITA, K ;

LIPSKY, PE .

ARTHRITIS AND RHEUMATISM, 1995, 38 (01) :96-104

[5] INTERLEUKIN-10 (IL-10) INHIBITS HUMAN LYMPHOCYTE INTERFERON GAMMA-PRODUCTION BY SUPPRESSING NATURAL-KILLER-CELL STIMULATORY FACTOR/IL-12 SYNTHESIS IN ACCESSORY CELLS [J].

DANDREA, A ;

ASTEAMEZAGA, M ;

VALIANTE, NM ;

MA, XJ ;

KUBIN, M ;

TRINCHIERI, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (03) :1041-1048

[6]

DING L, 1993, J IMMUNOL, V151, P1224

[7]

ESKDALE J, 1995, IMMUNOGENETICS, V42, P444

[8] 2 TYPES OF MOUSE T-HELPER CELL .4. TH2 CLONES SECRETE A FACTOR THAT INHIBITS CYTOKINE PRODUCTION BY TH1 CLONES [J].

FIORENTINO, DF ;

BOND, MW ;

MOSMANN, TR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (06) :2081-2095

[9]

FIORENTINO DF, 1991, J IMMUNOL, V147, P3815

[10] INTERLEUKIN-10 PRODUCTION BY HUMAN CARCINOMA CELL-LINES AND ITS RELATIONSHIP TO INTERLEUKIN-6 EXPRESSION [J].

GASTL, GA ;

ABRAMS, JS ;

NANUS, DM ;

OOSTERKAMP, R ;

SILVER, J ;

LIU, F ;

CHEN, M ;

ALBINO, AP ;

BANDER, NH .

INTERNATIONAL JOURNAL OF CANCER, 1993, 55 (01) :96-101

← 1 2 3 4 →