Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival

被引：61

作者：

Citro, Antonio ^{[1
,2
]}

Cantarelli, Elisa ^{[1
]}

Piemonti, Lorenzo ^{[1
]}

机构：

[1] Ist Sci San Raffaele, Diabet Res Inst, Beta Cell Biol Unit, I-20132 Milan, Italy

[2] Univ Pavia, Dept Surg, I-27100 Pavia, Italy

来源：

CURRENT DIABETES REPORTS | 2013年 / 13卷 / 05期

关键词：

Islet transplantation; Early innate immune events; Chemokines; Danger signals; Polymorphonuclear cells; Instant blood mediated inflammatory reaction; Anti-inflammatory strategies; Islet engraftment; Survival; MEDIATED INFLAMMATORY REACTION; WEIGHT DEXTRAN SULFATE; CHEMOKINE RECEPTORS CXCR1; ENDOTHELIAL-CELL GRAFTS; HUMAN PANCREATIC-ISLETS; TUMOR-NECROSIS-FACTOR; CASPASE INHIBITOR; TISSUE FACTOR; INTRAPORTAL TRANSPLANTATION; INSULIN INDEPENDENCE;

D O I：

10.1007/s11892-013-0401-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as "master regulator(s)" in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient).

引用

页码：733 / 744

页数：12

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