Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle

被引:440
作者
Telford, SR
Dawson, JE
Katavolos, P
Warner, CK
Kolbert, CP
Persing, DH
机构
[1] CTR DIS CONTROL & PREVENT, DIV VIRAL & RICKETTSIAL DIS, US DEPT HLTH & HUMAM SERV, ATLANTA, GA 30333 USA
[2] MAYO CLIN & MAYO FDN, ROCHESTER, MN 55905 USA
关键词
Ehrlichia; Ixodes dammini; mice; vector; reservoir;
D O I
10.1073/pnas.93.12.6209
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A human-derived strain of the agent of human granulocytic ehrlichiosis, a recently described emerging rickettsial disease, has been established by serial blood passage in mouse hosts, Larval deer ticks acquired infection by feeding upon such mice and efficiently transmitted the ehrlichiae after molting to nymphs, thereby demonstrating vector competence, The agent was detected hy demonstrating Feulgen-positive inclusions in the salivary glands of the experimentally infected ticks and from field-derived adult deer ticks. White-footed mice from a field site infected laboratory-reared ticks with the agent of human granulocytic ehrlichiosis, suggesting that these rodents serve as reservoirs for ehrlichiae as well as for Lyme disease spirochetes and the piroplasm that causes human babesiosis. About 10% of host-seeking deer ticks were infected with ehrlichiae, and of these, 20% also contained spirochetes. Cotransmission of diverse pathogens by the aggressively human-biting deer tick may have a unique impact on public health in certain endemic sites.
引用
收藏
页码:6209 / 6214
页数:6
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