A mild and chemoselective method for ester O-alkyl cleavage using in situ generated potassium thiophenoxide from catalytic quantities of base.

被引：18

作者：

Sharma, L

Nayak, MK

Chakraborti, AK

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, SAS Nagar 160062, India

[2] Univ Burdwan, Dept Chem, Burdwan 713104, W Bengal, India

来源：

TETRAHEDRON | 1999年 / 55卷 / 31期

关键词：

D O I：

10.1016/S0040-4020(99)00505-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemoselective deprotection of methyl esters can be achieved under non-hydrolytic and virtually neutral conditions by treatment with thiophenol in N-methyl-2-pyrrolidone (NMP) in the presence of a catalytic amount of K2C3. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：9595 / 9600

页数：6

共 41 条

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