The skin barrier, a well-organized membrane

被引：39

作者：

Bouwstra, JA

机构：

[1] Leiden/Amsterdam Ctr. for Drug Res., Leiden University, 2300 RA Leiden, P.O. Box 9502

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 1997年 / 123卷

关键词：

membrane; skin; transdermal drug delivery; X-RAY-DIFFRACTION; STRATUM-CORNEUM; PERMEABILITY BARRIER; CORNEOCYTE; WIDE;

D O I：

10.1016/S0927-7757(96)03819-8

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The natural function of the skin is the protection of the body against the loss of endogenous substances and the undesired influences from the environment caused by exogenous substances. The skin acts as a barrier against diffusion of substances through the underlying tissue. Overcoming this natural barrier is the main problem in dermal/transdermal delivery of drugs. The study of lipid organization which contain the skin dead cells will provide a greater understanding of the barrier function of the skin. The lipid phase behavior found in human, pig, and mouse stratum corneum as a function of hydration is summarized and presented.

引用

页码：403 / 413

页数：11

共 20 条

[1] THE LIPID AND PROTEIN-STRUCTURE OF MOUSE STRATUM-CORNEUM - A WIDE AND SMALL-ANGLE DIFFRACTION STUDY [J].