Genomics and the irreducible nature of eukaryote cells

被引:147
作者
Kurland, CG
Collins, LJ
Penny, D [1 ]
机构
[1] Massey Univ, Allan Wilson Ctr Mol Ecol & Evolut, Palmerston North, New Zealand
[2] Lund Univ, Dept Microbial Ecol, Lund, Sweden
关键词
D O I
10.1126/science.1121674
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Large-scale comparative genomics in harness with proteomics has substantiated fundamental features of eukaryote cellular evolution. The evolutionary trajectory of modern eukaryotes is distinct from that of prokaryotes. Data from many sources give no direct evidence that eukaryotes evolved by genome fusion between archaea and bacteria. Comparative genomics shows that, under certain ecological settings, sequence loss and cellular simplification are common modes of evolution. Subcellular architecture of eukaryote cells is in part a physical-chemical consequence of molecular crowding; subcellular compartmentation with specialized proteomes is required for the efficient functioning of proteins.
引用
收藏
页码:1011 / 1014
页数:4
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