11-deoxyfistularin-3, a new cytotoxic metabolite from the caribbean sponge Aplysina fistularis insularis

被引：50

作者：

Compagnone, RS

Avila, R

Suárez, AI

Abrams, OV

Rangel, HR

Arvelo, F

Piña, IC

Merentes, E

机构：

[1] Cent Univ Venezuela, Fac Ciencias, Ctr Quim Organ, Escuela Quim, Caracas, Venezuela

[2] Cent Univ Venezuela, Fac Farm, Caracas, Venezuela

[3] Cent Univ Venezuela, Fac Ciencias, Lab Cultivo Tejido Anim, Inst Expt Biol, Caracas, Venezuela

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 10期

关键词：

D O I：

10.1021/np9901938

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

11-Deoxyfistularin-3 (1), a new bromotyrosine derivative, was isolated among other known compounds such as fistularin-3 (2), aerothionin (3), and 11-oxoaerothionin (4) from the Caribbean sponge Aplysina fistularis (Aplysinellidae). The structure of 1 was determined by spectroscopic analysis and showed in vitro activity against the human breast carcinoma cell line MCF-7.

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页码：1443 / 1444

页数：2

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