Influence of hyperbaric oxygen therapy on peri-implant bone healing in rats with alloxan-induced diabetes

被引：14

作者：

Dutra Oliveira, Peterson Antonio ^{[1
]}

Soares Dutra Oliveira, Alcione Maria ^{[1
]}

Pablos, Aletheia Buosi

Costa, Fernando Oliveira ^{[2
]}

Borges Silva, Gerluza Aparecida ^{[3
]}

dos Santos, Jean Nunes ^{[4
]}

Cury, Patricia Ramos ^{[5
]}

机构：

[1] Pontificia Univ Catolica Minas Gerais, Dept Periodontol, Sch Dent, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Sch Dent, Dept Periodontol, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Biol Sci, Dept Morphol, Belo Horizonte, MG, Brazil

[4] Fed Univ Salvador, Sch Dent, Dept Oral Pathol, Salvador, BA, Brazil

[5] Fed Univ Salvador, Sch Dent, Dept Periodontol, Salvador, BA, Brazil

来源：

JOURNAL OF CLINICAL PERIODONTOLOGY | 2012年 / 39卷 / 09期

关键词：

bone healing; dental implants; diabetes; histometric analysis; hyperbaric oxygen therapy; COLLAGEN PRODUCTION; TITANIUM IMPLANTS; HYDROXYAPATITE IMPLANTS; METABOLIC-CONTROL; INSULIN THERAPY; DOMESTIC PIG; STREPTOZOTOCIN; MELLITUS; CELLS; DIFFERENTIATION;

D O I：

10.1111/j.1600-051X.2012.01922.x

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Aim The influence of hyperbaric oxygen therapy (HBOT) on peri-implant bone healing in rats with alloxan-induced type-1 diabetes was studied. Materials and methods Forty-eight male rats were randomly divided into six groups: (1) healthy rats (HR) that received no HBOT; (2) HR that underwent 10 sessions of HBOT before implant installation; (3) HR that underwent 10 sessions of HBOT after implant installation; (4) rats with induced diabetes (DR) without HBOT; (5) DR that underwent 10 sessions of HBOT before implant installation; (6) DR that underwent 10 sessions of HBOT after implant installation. A screw-shaped titanium implant was inserted into the femur. The animals were killed 28 days after implantation. The percentage of bone-to-implant contact (BIC) within the implant threads was evaluated. Results Lower BIC was observed in DR (35.35 +/- 18.04) compared with the HR (69.07 +/- 09.01) (p = 0.001). However, with HBOT, either before or after implantation, BIC was increased in DR. HBOT before implantation was p = 0.03; HBOT after implantation was p = 0.08. This increase reversed the negative effect of diabetes; therefore, the differences between DR and HR were not significant with HBOT (p = 0.21). Conclusion HBOT, either before or after implantation, increased the BIC in DR to the level of HR

引用

页码：879 / 886

页数：8

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