Reduction of telencephalin immunoreactivity in the brain of patients with Alzheimer's disease

被引：26

作者：

Hino, H

Mori, K

Yoshihara, Y

Iseki, E

Akiyama, H

Nishimura, T

Ikeda, K

Kosaka, K

机构：

[1] TOKYO INST PSYCHIAT,SETAGAYA KU,TOKYO 156,JAPAN

[2] YOKOHAMA CITY UNIV,SCH MED,DEPT PSYCHIAT,YOKOHAMA,KANAGAWA 236,JAPAN

[3] RIKEN,FRONTIER RES PROGRAM,LAB NEURONAL RECOGNIT MOL,WAKO,SAITAMA 35101,JAPAN

[4] OSAKA BIOSCI INST,DEPT NEUROSCI,OSAKA 565,JAPAN

[5] OSAKA MED COLL,DEPT BIOCHEM,OSAKA 569,JAPAN

来源：

BRAIN RESEARCH | 1997年 / 753卷 / 02期

关键词：

cell adhesion molecule; hippocampus; dendrite; neuron; human;

D O I：

10.1016/S0006-8993(97)00158-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Telencephalin (TLN) is a cell adhesion molecule expressed in the telencephalon of the mammalian central nervous system. We have investigated immunohistochemically the expression of TLN in human brain tissue from control subjects and patients with Alzheimer's disease (AD), In control brain, neuropil of the gray matter was stained diffusely with the anti-TLN antibody. TLN immunoreactivity was markedly decreased in the brain of AD patients, particularly in the hippocampal formation.

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页码：353 / 357

页数：5

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