Recovery from neuroendocrinological abnormalities and frontal hypoperfusion after remission in a case with rapid cycling bipolar disorder

被引：8

作者：

Shimizu, E ^{[1
]}

Kodama, K ^{[1
]}

Sakamoto, T ^{[1
]}

Komatsu, N ^{[1
]}

Yamanouchi, N ^{[1
]}

Okada, SI ^{[1
]}

Sato, T ^{[1
]}

机构：

[1] CHIBA MUNICIPAL HOSP, CHIBA, JAPAN

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 1997年 / 51卷 / 04期

关键词：

bipolar disorder; clonazepam; dexamethasone suppression test; hypothyroidism; rapid cycling affective disorder; single photon emission computed tomography;

D O I：

10.1111/j.1440-1819.1997.tb02584.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 51-year-old Japanese woman who had been suffering from a rapid cycling affective disorder (RCAD) for 24 years responded to combined clonazepam and carbamazepine therapy. Before remission, she showed neuroendocrinological and neuroimaging abnormalities such as subclinical hypothyroidism with exaggerated response to thyrotropin releasing hormone (TRH) inject-on, non-suppression on the dexamethasone suppression test (DST) and hypofrontality ill cerebral blood now. Her symptoms improved remarkably soon after adjunctive clonazepam treatment. After remission, her biological markers gradually returned to normal. First, subclinical hypothyroidism improved 2 months after remission. Next, hypofrontality disappeared 18 months later. Furthermore, non-suppression on the DST normalized 34 months later. The normalization of biological markers with apparent recovery from RCAD suggests a decreased risk of relapse into mood disorder. These findings reiterate the importance of following-up on the biological markers in RCAD for years after remission.

引用

页码：207 / 212

页数：6

共 33 条

[1] EVALUATION OF THYROID-FUNCTION IN PATIENTS WITH RAPID-CYCLING AND NON-RAPID-CYCLING BIPOLAR DISORDER [J].