Emerging pathogenic links between microbiota and the gut-lung axis

被引：1095

作者：

Budden, Kurtis F. ^{[1
,2
]}

Gellatly, Shaan L. ^{[1
,2
]}

Wood, David L. A. ^{[3
]}

Cooper, Matthew A. ^{[4
]}

Morrison, Mark ^{[5
]}

Hugenholtz, Philip ^{[3
,4
,5
]}

Hansbro, Philip M. ^{[1
,2
]}

机构：

[1] Univ Newcastle, Prior Res Ctr Hlth Lungs, Newcastle, NSW 2305, Australia

[2] Hunter Med Res Inst, Newcastle, NSW 2305, Australia

[3] Univ Queensland, Australian Ctr Ecogen, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia

[4] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[5] Univ Queensland, Diamantina Inst, Translat Res Inst, Woolloongabba, Qld 4012, Australia

来源：

NATURE REVIEWS MICROBIOLOGY | 2017年 / 15卷 / 01期

基金：

澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

REGULATORY T-CELLS; CHAIN FATTY-ACIDS; OBSTRUCTIVE PULMONARY-DISEASE; ALLERGIC AIRWAY INFLAMMATION; LIPOPOLYSACCHARIDE LPS REGULATION; CIGARETTE-SMOKE CONDENSATE; INFLUENZA-VIRUS INFECTION; IRRITABLE-BOWEL-SYNDROME; HELICOBACTER-PYLORI; INTESTINAL MICROBIOTA;

D O I：

10.1038/nrmicro.2016.142

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The microbiota is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut have recently been linked to alterations in immune responses and to disease development in the lungs. In this Opinion article, we review the microbial species that are usually found in healthy gastrointestinal and respiratory tracts, their dysbiosis in disease and interactions with the gut lung axis. Although the gut lung axis is only beginning to be understood, emerging evidence indicates that there is potential for manipulation of the gut microbiota in the treatment of lung diseases.

引用

页码：55 / 63

页数：9

共 131 条

[1] Low gut microbiota diversity in early infancy precedes asthma at school age [J].

Abrahamsson, T. R. ;

Jakobsson, H. E. ;

Andersson, A. F. ;

Bjorksten, B. ;

Engstrand, L. ;

Jenmalm, M. C. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2014, 44 (06) :842-850

[2] The relationship between bifidobacteria and allergic asthma and/or allergic dermatitis: A prospective study of 0-3 years-old children in Turkey [J].

Akay, Hatice Kubra ;

Tokman, Hrisi Bahar ;

Hatipoglu, Nevin ;

Hatipoglu, Huseyin ;

Siraneci, Rengin ;

Demirci, Mehmet ;

Borsa, Baris Ata ;

Yuksel, Pelin ;

Karakullukcu, Asiye ;

Kangaba, Achille Aime ;

Sirekbasan, Serhat ;

Aka, Sibel ;

Torun, Muzeyyen Mama ;

Kocazeybek, Bekir S. .

ANAEROBE, 2014, 28 :98-103

[3] Use of Germ-Free Animal Models in Microbiota-Related Research [J].

Al-Asmakh, Maha ;

Zadjali, Fahad .

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2015, 25 (10) :1583-1588

[4] Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut [J].

Allais, Liesbeth ;

Kerckhof, Frederiek-Maarten ;

Verschuere, Stephanie ;

Bracke, Ken R. ;

De Smet, Rebecca ;

Laukens, Debby ;

Van den Abbeele, Pieter ;

De Vos, Martine ;

Boon, Nico ;

Brusselle, Guy G. ;

Cuvelier, Claude A. ;

Van de Wiele, Tom .

ENVIRONMENTAL MICROBIOLOGY, 2016, 18 (05) :1352-1363

[5] Temporal trends in the incidence of multiple sclerosis [J].

Alonso, Alvaro ;

Hernan, Miguel A. .

NEUROLOGY, 2008, 71 (02) :129-135

[6] Early infancy microbial and metabolic alterations affect risk of childhood asthma [J].

Arrieta, Marie-Claire ;

Stiemsma, Leah T. ;

Dimitriu, Pedro A. ;

Thorson, Lisa ;

Russell, Shannon ;

Yurist-Doutsch, Sophie ;

Kuzeljevic, Boris ;

Gold, Matthew J. ;

Britton, Heidi M. ;

Lefebvre, Diana L. ;

Subbarao, Padmaja ;

Mandhane, Piush ;

Becker, Allan ;

McNagny, Kelly M. ;

Sears, Malcolm R. ;

Kollmann, Tobias ;

Mohn, William W. ;

Turvey, Stuart E. ;

Finlay, B. Brett .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (307)

[7] Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Oshima, Kenshiro ;

Suda, Wataru ;

Nagano, Yuji ;

Nishikawa, Hiroyoshi ;

Fukuda, Shinji ;

Saito, Takuro ;

Narushima, Seiko ;

Hase, Koji ;

Kim, Sangwan ;

Fritz, Joelle V. ;

Wilmes, Paul ;

Ueha, Satoshi ;

Matsushima, Kouji ;

Ohno, Hiroshi ;

Olle, Bernat ;

Sakaguchi, Shimon ;

Taniguchi, Tadatsugu ;

Morita, Hidetoshi ;

Hattori, Masahira ;

Honda, Kenya .

NATURE, 2013, 500 (7461) :232-+

[8] Siblings, day-care attendance, and the risk of asthma and wheezing during childhood [J].

Ball, TM ;

Castro-Rodriguez, JA ;

Griffith, KA ;

Holberg, CJ ;

Martinez, FD ;

Wright, AL .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (08) :538-543

[9] Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals [J].

Bassis, Christine M. ;

Erb-Downward, John R. ;

Dickson, Robert P. ;

Freeman, Christine M. ;

Schmidt, Thomas M. ;

Young, Vincent B. ;

Beck, James M. ;

Curtis, Jeffrey L. ;

Huffnagle, Gary B. .

MBIO, 2015, 6 (02)

[10] Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota [J].

Benjamin, Jane L. ;

Hedin, Charlotte R. H. ;

Koutsoumpas, Andreas ;

Ng, Siew C. ;

McCarthy, Neil E. ;

Prescott, Natalie J. ;

Pessoa-Lopes, Pedro ;

Mathew, Christopher G. ;

Sanderson, Jeremy ;

Hart, Ailsa L. ;

Kamm, Michael A. ;

Knight, Stella C. ;

Forbes, Alastair ;

Stagg, Andrew J. ;

Lindsay, James O. ;

Whelan, Kevin .

INFLAMMATORY BOWEL DISEASES, 2012, 18 (06) :1092-1100

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