The histamine H-1-antagonist chlorpheniramine facilitates learning in aged rats

被引:28
作者
Frisch, C
Hasenohrl, RU
Huston, JP
机构
[1] UNIV DUSSELDORF,INST PHYSIOL PSYCHOL,D-40225 DUSSELDORF,GERMANY
[2] UNIV DUSSELDORF,CTR BIOL & MED RES,D-40225 DUSSELDORF,GERMANY
关键词
histamine; chlorpheniramine; H-1-receptor; tuberomammillary nucleus; aging; inhibitory avoidance; old rat;
D O I
10.1016/S0304-3940(97)00422-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effect of the histamine H-1-receptor antagonist chlorpheniramine on inhibitory avoidance conditioning was investigated in 31-month-old rats, using a one-trial step-through avoidance task. Immediately after the learning trial, old rats were injected intraperitoneally with 5 or 10 mg/kg d-chlorpheniramine. Control groups included vehicle-injected old and adult (4-month-old) rats and a group of aged animals given an injection of 10 mg/kg chlorpheniramine 5 h after the training trial. When tested 24 h after training, aged rats receiving 10 mg/kg chlorpheniramine exhibited longer step-through latencies than vehicle-treated old controls, indicative of superior learning of the task. The hypermnestic effects of 10 mg/kg chlorpheniramine were no longer evident when injection was performed 5 h, rather than immediately after the learning trial, ruling out enduring proactive effects of the treatment on test performance. Furthermore, vehicle-treated old rats showed poorer inhibitory avoidance performance than vehicle-treated adult controls. Thus, the improvement in performance after the 10 mg/kg dose of chlorpheniramine can be interpreted in terms of a compensation of performance deficits in the old rats. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:89 / 92
页数:4
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