Localization of white matter volume increase in autism and developmental language disorder

被引:420
作者
Herbert, MR
Ziegler, DA
Makris, N
Filipek, PA
Kemper, TL
Normandin, JJ
Sanders, HA
Kennedy, DN
Caviness, VS
机构
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Morphometr Anal, Cambridge, MA 02138 USA
[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Neurol, Cambridge, MA 02138 USA
[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol, Cambridge, MA 02138 USA
[4] Univ Calif Irvine, Coll Med, Dept Pediat, Irvine, CA 92717 USA
[5] Univ Calif Irvine, Coll Med, Dept Neurol, Irvine, CA 92717 USA
[6] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02215 USA
[7] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA
关键词
D O I
10.1002/ana.20032
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Increased brain volume in autism appears to be driven mainly by an unexplained white matter enlargement, and we have reported a similar phenomenon in developmental language disorder (DLD). Localization of this enlargement would strongly guide research into its cause, tissue basis, and functional implications. We utilized a white matter parcellation technique that divides cerebral white matter into an outer zone containing the radiate compartment and an inner zone containing sagittal and bridging system compartments. In both high-functioning autism and DLD, enlargement localized to the radiate white matter (all lobes in autism, all but parietal in DLD), whereas inner zone white matter compartments showed no volume differences from controls. Furthermore, in both autism and DLD, later or longer-myelinating regions showed greater volume increases over controls. Neither group showed cerebral cortex, corpus callosum, or internal capsule volume differences from control. Radiate white matter myelinates later than deep white matter; this pattern of enlargement thus is consistent with striking postnatal head circumference percentile increases reported in autism. These findings suggest an ongoing postnatal process in both autism and DLD that is probably intrinsic to white matter, that primarily affects intrahemispheric and corticocortical connections, and that places these two disorders on the same spectrum.
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页码:530 / 540
页数:11
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