Discovery of Chemoselective and Biocompatible Reactions Using a High-Throughput Immunoassay Screening

被引：108

作者：

Kolodych, Sergii ^{[1
]}

Rasolofonjatovo, Evelia ^{[1
]}

Chaumontet, Manon ^{[1
]}

Nevers, Marie-Claire ^{[2
]}

Creminon, Christophe ^{[2
]}

Taran, Frederic ^{[1
]}

机构：

[1] CEA, iBiTecS, Serv Chim Bioorgan & Marquage, F-91191 Gif Sur Yvette, France

[2] CEA, iBiTecS, Serv Pharmacol & Immunoanal, F-91191 Gif Sur Yvette, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 46期

关键词：

click chemistry; copper; high-throughput screening; immunoassay; reaction discovery; DNA-TEMPLATED SYNTHESIS; CLICK CHEMISTRY; CYCLOADDITION; SYDNONE; STRATEGY;

D O I：

10.1002/anie.201305645

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An immunoassay-based method was used to screen numerous combinations of dipoles and dipolarophiles for their ability to undergo chemoselective and biocompatible [3+2] cycloaddition reactions. The approach fulfills most of the requirements of the click concept and led to the discovery of a copper-catalyzed reaction that generates pyrazoles from sydnone and alkyne reagents. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12056 / 12060

页数：5

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