Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

被引：174

作者：

Carrizzo, Albino ^{[1
]}

Forte, Maurizio ^{[2
]}

Damato, Antonio ^{[1
]}

Trimarco, Valentina ^{[3
]}

Salzano, Francesco ^{[4
]}

Bartolo, Michelangelo ^{[5
]}

Maciag, Anna ^{[6
]}

Puca, Annibale A. ^{[6
,7
]}

Vecchione, Carmine ^{[1
,7
]}

机构：

[1] IRCCS INM Neuromed, Vasc Pathophysiol Unit, Pozzilli, IS, Italy

[2] Univ Naples Federico II, Dept Biol, Naples, Italy

[3] Univ Naples Federico II, Dept Neurosci, Naples, Italy

[4] Univ Palermo, Dept Surg Oncol & Dent Disciplines, I-90133 Palermo, Italy

[5] IRCCS INM Neuromed, NeuroRehabil Unit, Pozzilli, IS, Italy

[6] IRCCS Multimed, Cardiovasc Res Unit, Milan, Italy

[7] Univ Salerno, Dept Med & Surg, I-84100 Salerno, Italy

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 61卷

关键词：

Oxidative stress; Nitric oxide; Antioxidant; Cardiovascular; Brain; Diabetes; NITRIC-OXIDE SYNTHASE; IMPROVES INSULIN SENSITIVITY; ATTENUATES OXIDATIVE STRESS; SMOOTH-MUSCLE-CELLS; FACTOR-KAPPA-B; RED WINE; TRANS-RESVERATROL; ENDOTHELIAL FUNCTION; POLYGONUM-CUSPIDATUM; PHENOLIC-COMPOUNDS;

D O I：

10.1016/j.fct.2013.07.021

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Resveratrol a natural polyphenolic compound was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: (a) the sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and health-related use. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：215 / 226

页数：12

共 180 条

[1]

Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications [J].

Alarcn de la Lastral, C. ;

Villegas, I. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2007, 35 :1156-1160

[2]

Sirtuin activators [J].

Alcain, Francisco J. ;

Villalba, Jose M. .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2009, 19 (04) :403-414

[3]

Functional Foods and Nutraceuticals in the Primary Prevention of Cardiovascular Diseases [J].

Alissa, Eman M. ;

Ferns, Gordon A. .

JOURNAL OF NUTRITION AND METABOLISM, 2012, 2012

[4]

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers [J].

Almeida, Luis ;

Vaz-da-Silva, Manuel ;

Falcao, Amilcar ;

Soares, Eva ;

Costa, Raquel ;

Loureiro, Ana I. ;

Fernandes-Lopes, Carlos ;

Rocha, Jose-Francisco ;

Nunes, Teresa ;

Wright, Lyndon ;

Soares-da-Silva, Patricio .

MOLECULAR NUTRITION & FOOD RESEARCH, 2009, 53 :S7-S15

[5]

AndresLacueva C., 2009, PLANT PHENOLICS HUMA, P265

[6]

Some Phenolic Compounds Increase the Nitric Oxide Level in Endothelial Cells in Vitro [J].

Appeldoorn, Maaike M. ;

Venema, Dini P. ;

Peters, Theodorus H. F. ;

Koenen, Marjorie E. ;

Arts, Ilja C. W. ;

Vincken, Jean-Paul ;

Gruppen, Harry ;

Keijer, Jaap ;

Hollman, Peter C. H. .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2009, 57 (17) :7693-7699

[7]

Metabolites and tissue distribution of resveratrol in the pig [J].

Azorin-Ortuno, Maria ;

Yanez-Gascon, Maria J. ;

Vallejo, Fernando ;

Pallares, Francisco J. ;

Larrosa, Mar ;

Lucas, Ricardo ;

Morales, Juan C. ;

Tomas-Barberan, Francisco A. ;

Garcia-Conesa, Maria T. ;

Espin, Juan C. .

MOLECULAR NUTRITION & FOOD RESEARCH, 2011, 55 (08) :1154-1168

[8]

Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[9]

Therapeutic potential of resveratrol:: the in vivo evidence [J].

Baur, Joseph A. ;

Sinclair, David A. .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (06) :493-506

[10]

Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women [J].

Bhavnani, BR ;

Cecutti, A ;

Gerulath, A ;

Woolever, AC ;

Berco, M .

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2001, 8 (06) :408-419

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