A short cerebral ischemic preconditioning up-regulates adenosine receptors in the hippocampal CA1 region of rats

被引：76

作者：

Zhou, AM ^{[1
]}

Li, WB ^{[1
]}

Li, QJ ^{[1
]}

Liu, HQ ^{[1
]}

Feng, RF ^{[1
]}

Zhao, HG ^{[1
]}

机构：

[1] Hebei Med Univ, Inst Basic Med, Dept Pathophysiol, Shijiazhuang 050017, Peoples R China

来源：

NEUROSCIENCE RESEARCH | 2004年 / 48卷 / 04期

关键词：

cerebral ischemic preconditioning; neuroprotection; expression of adenosine receptors;

D O I：

10.1016/j.neures.2003.12.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Pharmacologically blocking or stimulating studies have showed the crucial role of adenosine receptors in the protective effect of cerebral ischemic preconditioning (CIP). However, little is know about whether the adenosine receptors are up-regulated in the process. In the present study, changes in expression of adenosine receptors in the CA1 hippocampus after a short CIP in a period of 3 min were investigated in rat four-vessel occluding (4VO) brain ischemic model using immunohistochemistry. The experiments were performed on groups of sham, 4 h, 1, 3, and 7 days (n = 6 in each group) after the CIP. The number and immunostaining density of immunoreactive cells for A1 and A2b adenosine receptors in the CA1 hippocampus were significantly increased after the CIP. For A1 adenosine receptor, the increase occurred in CA1 pyramidal neurons. While for A2b adenosine receptor, the increase occurred in the stratum radiatum of the CA1. The immunoreactive cells for A2b receptor showed distinct morphological characteristics of astrocytes. The increases were consistent in time course (1-7 days) with the development of the ischemic tolerance induced by the CIP. It was concluded that up-regulation of adenosine receptors may also play an important role in the protective effect of CIP. (C) 2004 Elsevier Ireland Ltd and The Japan Neuroscience Society. All rights reserved.

引用

页码：397 / 404

页数：8

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