Humoral immune response of dengue hemorrhagic fever cases in children from Tegucigalpa, Honduras

被引：12

作者：

De Rivera, Ivette Lorenzana

Parham, Leda

Murillo, Wendy

Moncada, Walter

Vazquez, Susana

机构：

[1] Natl Autonomous Univ Honduras, Dept Microbiol, Tegucigalpa, Honduras

[2] Social Secur Hosp Honduras, Tegucigalpa, Honduras

[3] Pedro Kouri Inst, PAHO WHO, Collaborating Ctr Study Dengue & Vector, Havana, Cuba

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2008年 / 79卷 / 02期

关键词：

D O I：

10.4269/ajtmh.2008.79.262

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The humoral immune response in Honduran dengue hemorrhagic fever (DHF) hospitalized pediatric cases from the epidemics of 2004 and 2005 was studied in sera collected from 5 to 7 days of fever onset. A total of 145 cases were included in the study: 40 classified as primary with DHF Grade I or II and 86 classified as secondary: from them, 73 were DFIF Grade I or II and 13 were dengue shock syndrome (DSS) Grade III or IV. The highest number of primary cases was found in children < 1 year of age. The highest number of secondary cases was observed in children between 5 and 10 years of age. The IgA values showed a statistically significant difference between primary and secondary groups. The relationship between antibody responses and severity grade is discussed. This is the first study related to the humoral immune response and severity grade in DHF cases in Honduran children.

引用

页码：262 / 266

页数：5

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