Heterodyne coherent anti-Stokes Raman scattering (CARS) imaging

被引:272
作者
Potma, EO [1 ]
Evans, CL [1 ]
Xie, XS [1 ]
机构
[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA
关键词
D O I
10.1364/OL.31.000241
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We have achieved rapid nonlinear vibrational imaging free of nonresonant background with heterodyne coherent anti-Stokes Raman scattering (CARS) interferometric microscopy. This technique completely separates the real and imaginary responses of nonlinear susceptibility chi((3)) and yields a signal that is linear in the concentration of vibrational modes. We show that heterodyne CARS microscopy permits the detection of weak vibrational resonances that are otherwise overshadowed by the strong interference of the nonresonant background. (c) 2006 Optical Society of America.
引用
收藏
页码:241 / 243
页数:3
相关论文
共 7 条
[1]   Coherent anti-Stokes Raman scattering microscopy: Instrumentation, theory, and applications [J].
Cheng, JX ;
Xie, XS .
JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (03) :827-840
[2]   Polarization coherent anti-Stokes Raman scattering microscopy [J].
Cheng, JX ;
Book, LD ;
Xie, XS .
OPTICS LETTERS, 2001, 26 (17) :1341-1343
[3]   An epi-detected coherent anti-stokes raman scattering (E-CARS) microscope with high spectral resolution and high sensitivity [J].
Cheng, JX ;
Volkmer, A ;
Book, LD ;
Xie, XS .
JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (07) :1277-1280
[4]   Coherent anti-Stokes Raman scattering spectral interferometry:: determination of the real and imaginary components of nonlinear susceptibility χ(3) for vibrational microscopy [J].
Evans, CL ;
Potma, EO ;
Xie, XSN .
OPTICS LETTERS, 2004, 29 (24) :2923-2925
[5]  
HELLWARTH RW, 1977, PROGR QUANTUM ELECT, P1
[6]   Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy [J].
Nan, XL ;
Cheng, JX ;
Xie, XS .
JOURNAL OF LIPID RESEARCH, 2003, 44 (11) :2202-2208
[7]   Time-resolved coherent anti-Stokes Raman scattering microscopy: Imaging based on Raman free induction decay [J].
Volkmer, A ;
Book, LD ;
Xie, XS .
APPLIED PHYSICS LETTERS, 2002, 80 (09) :1505-1507