Identification of mutations related to streptomycin resistance in clinical isolates of Mycobacterium tuberculosis and possible involvement of efflux mechanism

被引：85

作者：

Spies, Fernanda S. ^{[2
]}

da Silva, Pedro E. Almeida ^{[3
]}

Ribeiro, Marta O. ^{[2
]}

Rossetti, Maria Lucia ^{[2
,4
]}

Zaha, Arnaldo ^{[1
,5
]}

机构：

[1] Univ Fed Rio Grande do Sul, Ctr Biotecnol, Programa Posgrad Genet & Biol Mol, BR-91501970 Porto Alegre, RS, Brazil

[2] Fundacao Estadual Prod & Pesquisa Saude Estado Ri, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande, Posgrad Ciencias Saude, Campus Da Saude, Rio Grande, Brazil

[4] Univ Luterana Brasil, Programa Posgrad Ciencias Genet & Toxicol Aplicad, Canoas, Brazil

[5] Univ Fed Rio Grande do Sul, Ctr Biotecnol, Porto Alegre, RS, Brazil

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 08期

关键词：

D O I：

10.1128/AAC.01570-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The MIC for streptomycin in the presence of efflux pump (EP) inhibitors and the sequencing of rpsL, rrs, and gidB genes provided evidence for the possible participation of EP in low-level streptomycin (STR) resistance of some isolates without mutations. Mutation in the gidB gene and an EP could act synergistically to confer low STR resistance.

引用

页码：2947 / 2949

页数：3

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