Stress-induced enhancement of auditory startle: An animal model of posttraumatic stress disorder

被引:44
作者
Garrick, T
Morrow, N
Shalev, AY
Eth, S
机构
[1] W Los Angeles Vet Affairs Med Ctr, Los Angeles, CA 90073 USA
[2] Hadassah Univ Hosp, IL-91120 Jerusalem, Israel
[3] St Vincents Catholic Med Ctr New York, New York, NY USA
来源
PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES | 2001年 / 64卷 / 04期
关键词
D O I
10.1521/psyc.64.4.346.18600
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
AN innovative animal model of, posttraumatic stress disorder (PTSD) is proposed in which nonhabituation of the acoustic startle response is developed in rats subsequent to tailshock exposure. Subjects (n = 3 1) received 3 0 minutes of intermittent tail shock on 2 days followed by exposure to the tailshock apparatus on the third day. Compared to baseline startle reactions, 9 of 31 tailshock-exposed rats developed nonhabituation of startle response reactions during the subsequent 3 weeks of testing. No control rats developed nonhabituation of startle reactions over a similar time period. These data suggest that this system models useful aspects of clinical PTSD emphasizing nonhabituation of startle reactions as a dependent variable. The method consistently identifies a subgroup of rats that develop persistent nonhabituation of startle in response to a tailshock-stress paradigm.
引用
收藏
页码:346 / 354
页数:9
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