Advances in Glucocorticoid-Induced Osteoporosis

被引：140

作者：

den Uyl, Debby ^{[1
]}

Bultink, Irene E. M. ^{[1
]}

Lems, Willem F. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Rheumatol, NL-1081 HV Amsterdam, Netherlands

来源：

CURRENT RHEUMATOLOGY REPORTS | 2011年 / 13卷 / 03期

关键词：

Bone; Glucocorticoids; Osteoporosis; CORTICOSTEROID-INDUCED OSTEOPOROSIS; INDUCED BONE LOSS; DOUBLE-BLIND; VERTEBRAL FRACTURE; MINERAL DENSITY; RISEDRONATE; ALENDRONATE; MECHANISMS; DIFFERENTIATION; PREVENTION;

D O I：

10.1007/s11926-011-0173-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucocorticoid-induced osteoporosis (GIOP) is one of the most important side effects of glucocorticoid use, as it leads to an increased risk of fractures. Recently, many published studies have focused on the cellular and molecular mechanisms of bone metabolism, the pathophysiology of GIOP, and the intervention options to prevent GIOP. In this review, recent advances in GIOP are summarized, particularly recent progress in our understanding of the mechanisms of GIOP resulting in improved insight that might result in the development of new treatment options in the near future.

引用

页码：233 / 240

页数：8

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