Interpretation of Changes in Circulating Tumor Cell Counts

被引：36

作者：

Coumans, Frank A. W. ^{[1
]}

Ligthart, Sjoerd T. ^{[1
]}

Terstappen, Leon W. M. M. ^{[1
]}

机构：

[1] Univ Twente, Dept Med Cell Biophys, MIRA Inst, NL-7522 NH Enschede, Netherlands

来源：

TRANSLATIONAL ONCOLOGY | 2012年 / 5卷 / 06期

关键词：

METASTATIC BREAST-CANCER; RESISTANT PROSTATE-CANCER; PERIPHERAL-BLOOD; PROGRESSION-FREE; LUNG-CANCER; SURVIVAL; MARKER; TRIAL;

D O I：

10.1593/tlo.12247

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The presence of circulating tumor cells (CTCs) in the blood of cancer patients may guide the use of therapy. We investigated how to evaluate a reduction in the number of CTCs after administration of therapy. CTCs were enumerated with the CellSearch system in 111 metastatic breast and 185 metastatic prostate cancer patients before start of a new line of chemotherapy and after initiation of therapy. Different means to express changes in CTC counts were evaluated with respect to overall survival (OS). A static CTC cutoff is the best method to determine whether a therapy is effective. This is exemplified by the highest Cox hazard ratio of 2.1 for OS; three methods to express relative differences performed worse. A lookup table is provided from which the significance of a change in CTCs can be derived. The aim of therapy should be the elimination of all CTCs. A period of 10 to 12 weeks of therapy is needed to reach the treatment effect on CTCs. Translational Oncology (2012) 5, 486-491

引用

页码：486 / 491

页数：6

共 22 条

[1] Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases [J].

Allard, WJ ;

Matera, J ;

Miller, MC ;

Repollet, M ;

Connelly, MC ;

Rao, C ;

Tibbe, AGJ ;

Uhr, JW ;

Terstappen, LWMM .

CLINICAL CANCER RESEARCH, 2004, 10 (20) :6897-6904

[2] Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer [J].

Bidard, F. -C. ;

Mathiot, C. ;

Delaloge, S. ;

Brain, E. ;

Giachetti, S. ;

de Cremoux, P. ;

Marty, M. ;

Pierga, J. -Y. .

ANNALS OF ONCOLOGY, 2010, 21 (04) :729-733

[3] Circulating tumor cells versus imaging - Predicting overall survival in metastatic breast cancer [J].

Budd, G. Thomas ;

Cristofanilli, Massimo ;

Ellis, Mathew J. ;

Stopeck, Allison ;

Borden, Ernest ;

Miller, M. Craig ;

Matera, Jeri ;

Repollet, Madeline ;

Doyle, Gerald V. ;

Terstappen, Leon W. M. M. ;

Hayes, Daniel F. .

CLINICAL CANCER RESEARCH, 2006, 12 (21) :6403-6409

[4] Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer [J].

Cohen, Steven J. ;

Punt, Cornelis J. A. ;

Iannotti, Nicholas ;

Saidman, Bruce H. ;

Sabbath, Kert D. ;

Gabrail, Nashat Y. ;

Picus, Joel ;

Morse, Michael ;

Mitchell, Edith ;

Miller, M. Craig ;

Doyle, Gerald V. ;

Tissing, Henk ;

Terstappen, Leon W. M. M. ;

Meropol, Neal J. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (19) :3213-3221

[5]

Coumans FAW, 2012, CLIN CANCER RES, DOI [10.1158/1078-0432, DOI 10.1158/1078-0432]

[6] Circulating tumor cells, disease progression, and survival in metastatic breast cancer [J].

Cristofanilli, M ;

Budd, GT ;

Ellis, MJ ;

Stopeck, A ;

Matera, J ;

Miller, MC ;

Reuben, JM ;

Doyle, GV ;

Allard, WJ ;

Terstappen, LWMM ;

Hayes, DF .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (08) :781-791

[7] Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer [J].

de Bono, Johann S. ;

Scher, Howard I. ;

Montgomery, R. Bruce ;

Parker, Christopher ;

Miller, M. Craig ;

Tissing, Henk ;

Doyle, Gerald V. ;

Terstappen, Leon W. W. M. ;

Pienta, Kenneth J. ;

Raghavan, Derek .

CLINICAL CANCER RESEARCH, 2008, 14 (19) :6302-6309

[8] Circulating tumor cells and bone metastases as detected by FDG-PET/CT in patients with metastatic breast cancer [J].

De Giorgi, U. ;

Valero, V. ;

Rohren, E. ;

Mego, M. ;

Doyle, G. V. ;

Miller, M. C. ;

Ueno, N. T. ;

Handy, B. C. ;

Reuben, J. M. ;

Macapinlac, H. A. ;

Hortobagyi, G. N. ;

Cristofanilli, M. .

ANNALS OF ONCOLOGY, 2010, 21 (01) :33-39

[9]

de Groot MR, 2007, P AN M AM SOC CLIN, V25, p18S

[10]

de Groot MR, 2007, P AN M AM SOC CLIN, V25, P14512

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