The fusion protein of peste des petits ruminants virus is a hemolysin

被引:20
作者
Devireddy, LR
Raghavan, R
Ramachandran, S
Shaila, MS
机构
[1] Vet Coll, Dept Vet Microbiol, Bangalore, Karnataka, India
[2] Univ Edinburgh, Ctr Trop Vet Med, Roslin, Midlothian, Scotland
[3] Indian Inst Sci, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India
关键词
D O I
10.1007/s007050050583
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The fusion glycoprotein (F protein) of paramyxoviruses plays a vital role in virus-induced cytopathology. To explore the role of the F protein in peste des petits ruminants virus (PPRV)-induced cytopathology, the F protein of PPRV was purified by immunoaffinity chromatography. The purified F protein, when incubated with chicken erythrocytes, caused lysis suggesting that PPRV F protein is a hemolysin. Furthermore, the hemolysis can be inhibited by hyperimmune serum against F protein. The virus-induced cell fusion (syncytia) was also inhibited by the hyperimmune serum against the F protein. In summary, these results indicate that the purified PPRV F protein is biologically active and is involved in virus-induced hemolysis, cell-fusion and the initiation of infection.
引用
收藏
页码:1241 / 1247
页数:7
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