Effects of repeated high-dose methamphetamine on local cerebral glucose utilization in rats

被引:20
作者
Huang, YH [1 ]
Tsai, SJ
Su, TW
Sim, CB
机构
[1] Natl Yang Ming Univ, Inst Dept Anat, Taipei 112, Taiwan
[2] Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan
[3] Natl Yang Ming Univ, Sch Med, Div Neuropsychiat, Taipei 112, Taiwan
关键词
deoxyglucose; methamphetamine; neurotoxicity; striatum; rat;
D O I
10.1016/S0893-133X(99)00029-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Repeated administration of high doses of methamphetamine (MAP) to rats can induce long-lasting neurotoxicity which may be related to permanent psychotic symptoms and negative symptoms in some MAP psychotic patients. In this study, we used the 2-[C-14]deoxyglucose (2DG) method to analyze the effects of repeated MAP administration (12.5 mg/kg, i.p., 4 times every 2 hr within a day) 14 days and 60 days after drug administration. The results showed a widespread (26 of the 43 regions examined) decreases in the regional cerebral glucose utilization. The regions with decrease metabolism included all the extrapyramidal systems, the hippocampus formation and dorsal raphe nucleus. Rats tested 60 days after drug administration has similar finding to those with a 14-day abstinent period. The results of the functional change in this study provide support for the neurotoxic effects of repented high dose MAP administration in mts. Furthermore, the neurotoxic effects are selective and long-lasting. We suggested the MAP neurotoxic model can be used to study the permanent psychosis and negative symptoms of MAP-induced psychosis in humans. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
引用
收藏
页码:427 / 434
页数:8
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