1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties

被引：15

作者：

Kozikowski, AP

Araldi, GL

Tückmantel, W

Pshenichkin, S

Surina, E

Wroblewski, JT

机构：

[1] Georgetown Univ, Med Ctr, Drug Discovery Lab, Inst Cognit & Computat Sci, Washington, DC 20007 USA

[2] Georgetown Univ, Med Ctr, Dept Pharmacol, Washington, DC 20007 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(99)00266-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity, (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1721 / 1726

页数：6

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